Joao Pedro has put Chelsea in front against Burnley in the late kick-off, while Brighton celebrate goals from Danny Welbeck and Diego Gomez against Brentford.
Elsewhere, Leeds have taken the lead at Aston Villa in the other 3pm fixtures.
Chelsea lead vs Burnley as Brighton and Leeds score
Saturday's 3pm Premier League action sees Chelsea leading Burnley, while Brighton and Leeds take early leads against Brentford and Aston Villa respectively.